Pharmacokinetics and pharmacodynamics of R- and S-gallopamil during multiple dosing
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چکیده
منابع مشابه
Pharmacokinetics and pharmacodynamics of the enantiomers of gallopamil.
The pharmacokinetics and pharmacodynamics of the enantiomers of the calcium antagonist gallopamil have been investigated in six healthy volunteers. Each subject was studied on five occasions after receiving, in randomized order: placebo, 25 mg of (R)-gallopamil, 25 mg of (S)-gallopamil, 50 mg of pseudoracemic [25 mg of deuterated (S)-gallopamil and 25 mg of (R)-gallopamil] and 100 mg of (R)-gal...
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AIMS To study the pharmacokinetics of vigabatrin in a patient affected with tuberous sclerosis who developed major agitation and aggression, while receiving vigabatrin orally (1.5 g every 12 h) and in whom impaired renal function was diagnosed. METHODS The patient received vigabatrin (0.5 g day(-1)). A pharmacokinetic study of the S(+) and R(-) enantiomers of vigabatrin was performed before a...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2000
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2000.00115.x